Cancer patient finds hope – and remission – in CAR T therapy

Cancer patient finds hope – and remission – in CAR T therapy

When Novartis announced that the U.S. Food and Drug Administration (FDA) had approved Kymriah, the first chimeric antigen receptor T cell (CAR T) therapy, for the treatment of patients up to 25 years of age with a form of leukemia, it was a breakthrough for precision medicine.

The therapy uses Cell Therapy Systems (CTS) Dynabeads technology, developed by Thermo Fisher, to activate and expand T cells that have been genetically engineered to recognize and fight cancers unique to each patient. This all starts with the patient’s own cells, which are infused back into them after the process is complete.

Nicole Gularte’s cells took this same journey, and today she remains cancer-free. But her road was far from easy. After being diagnosed with acute lymphoblastic leukemia (ALL) in 2010, and spending the next six years in and out of cancer treatments, the novel precision medicine approach was her last hope: She was exhausted and had exhausted all options.

Gularte, 32, answered questions about her journey for Life in the Lab.

Life in the Lab: At what stage in your battle with cancer did you first learn about CAR T cell therapy?

Nicole Gularte: After a relapse in 2014, my doctors at the University of Stanford told me that I would need a transplant and that I’d be looking at 3-5 more years of additional treatment with a lot of side-effects and a low percentage of success. I kept pushing because there just had to be another option, and that’s when they mentioned CAR T.  But they told me that I wouldn’t live to see CAR-T treatments reach clinical trials and not to think about it because it would be a waste of my time. I left the hospital vowing to do my own research, and, in the meantime, I took part in a clinical trial for an antibody called Inotuzumab. Initially the treatment worked, but, more importantly, it served as a bridge to getting to CAR T.

LITL: So, if you considered it a bridge, does that mean you knew Inotuzumab was likely not a long-term solution?

NG: Yes. We knew Inotuzumab would likely put me in remission overnight, but we also knew that the antibody lacked the receptor that stays on to target and kill the cancer cells. So, despite being in remission, we knew the cancer would come back. But it bought me time and during that time, I pushed myself to pursue CAR T because I actually realized new drugs could work, and with far less toxicities. Until that point, my chemotherapy treatments were doing cumulative damage to my body, and I still suffer from side-effects.

LITL: Inotuzamab had no long-term side-effects?

NG: No, there are no long-term side-effects from Inotuzumab. I went into remission immediately after getting Inotuzumab but didn’t lose my hair or nails and didn’t feel sick. This experience gave me confidence and hope for the CAR T therapy.

LITL: And you had to cross the country to be in position for a CAR T trial, correct?

NG: Exactly. When I was first in remission from Inotuzumab in 2014, I called the University of Pennsylvania, which had a CAR T trial on hold, but I had a strong feeling that it would eventually come back because of the initial studies and the success rates. So UPenn granted me an appointment and although they knew I would eventually relapse, I was healthy at the time. They collected and froze my cells for when either the FDA lifted the hold on the study or I relapsed, which is what I needed to do to qualify for the study.

LITL: And what was it like for you to play the waiting game before you finally qualified for the CAR T trial?

NG: For two years, from 2014-2016, I traveled, shared my story and raised awareness while I was getting treatments. I had relapsed several times in my eyes and the leukemia had spread into my spinal fluid which kept me from being qualified for the study. And even though I was happy and still wanted to fight, the combination of chemotherapy that was injected in my spine every day and radiation was toxic, and it was diminishing my quality of life. That’s when I decided to go on palliative care and stop treatment. When they gave me 3-5 weeks to live, I decided to start planning my funeral. And since I was never baptized, my family and friends arranged for my baptism. I lived those weeks thinking they would be my last.

LITL: And then what happened?

NG: Miraculously, days before I was supposed to be dead, I had a final check-up and although the cancer didn’t go away, my blood was good and the leukemia was no longer detected in my spinal fluid which qualified me for the study. The next week I flew out to UPenn and got the treatment. The experience was amazing and within 28 days, my leukemia was gone. It was crazy because I went from having it spread to my eyes, my spine, my lymph nodes and my bone marrow to it being gone.

LITL: How are you feeling today? And what’s next for you?

NG: Last October, I had my annual checkup, which confirmed that I have no leukemia cells anywhere. I’ve also become very involved with the Emily Whitehead Foundation and was honored to be a speaker at the inaugural gala, which included more than 30 CAR T survivors – all children, aside from me. After that event and my clean checkup, I’ve made my purpose in life to be a voice for children with cancer, and I’m now launching a west coast operation of the Emily Whitehead Foundation.

To learn more about Nicole Gularte’s story, visit her blog: The Inspired Hero – Leading The Way With Immunotherapy.



The Emily Whitehead Foundation


Kari, Emily and Tom at the NYC Gala, 2015


The Emily Whitehead Foundation (EWF) is a nonprofit company organized by Tom and Kari Whitehead on behalf of the treatment that their daughter, Emily, received in 2012.  Emily is the first pediatric patient to receive CAR T-cell therapy.  The foundation’s purpose is to raise money and awareness for childhood cancers and cancer research.  I was first diagnosed with children’s Acute Lymphoblastic Leukemia in 2010.  Facing more relapses and less options, I began to research T-cell therapy.  Emily has been my hero for nearly three years – since I first watched her T-cell story in the YouTube video, Fire with Fire, by Ross Kauffman.  Her story has kept me inspired and has given me the courage to keep fighting for T-cell therapy and awareness.  


During my struggle to gain access to CAR T-cell therapy at The University of Pennsylvania, I faced several problems that included:

  • Disqualification from the study
  • Discouragement and loss of hope
  • Loss of travel funds


I first reached out to Tom in July 2016, in an effort to obtain guidance from an expert in patient care and advocacy with T-cell therapy.  Although I qualified for the CAR T-cell trial in April 2016, I experienced a relapse in the central nervous system (CNS) which immediately disqualified me from the study.  After six years of battling ALL coupled with another relapse, I began to lose hope.  I chose to reach out to the EWF, because I knew Tom and Kari Whitehead would have a great deal of knowledge and experience in T-cell therapy and patient advocacy.


  • Reliable source of contact
  • Patient advocacy
  • Prayer
  • Assistance with travel arrangements


In early August, I explained to Tom that I no longer qualified for the trial, and that I was tired of fighting.  I stopped all treatments and a Stanford pallative care team had given me three to five weeks to live.  Tom told me not to give up and said that things would fall into place.  He assured me that he and the EWF would continue to help get me out to Philadelphia for treatment. His words eased my fears and frustration.  He helped me regain focus and get back on track in my efforts.  The EWF community added me to prayer lists, while Tom made dozens of phone calls in an attempt to get me out to Philadelphia.  Tom advocated on my behalf, stood up for my rights, and encouraged me to reach out to others who once faced similar situations.

After a trip back to Stanford per Tom’s recommendation, doctors confirmed a miracle – my blood looked normal and my spinal resutls showed no leukemia cells in the CNS.  At this point I had not received chemotherapy or blood transfusions for several weeks, so it is very unusual that my labs would look so good.  This meant that I qualified for the T-cell therapy trial.  Tom immediately put me in contact with someone who quickly arranged flights for me and a friend.


  • Received T-cells
  • Cancer free
  • Future advocate


I am most grateful to the Whiteheads for coming into my life during my time of need.  The EWF community restored the hope I once lost and they showed me what it was like to believe all over again.  The Whiteheads were instrumental in getting me out to Philadelphia for the CAR T-cell treatment.  The EWF’s  community had a major impact throughout my CAR T-cell journey at The University of Pennsylvania.  If not for them, I would not have received my treatment.


The EWF has created a vast community – connecting patients, parents, fighters, survivors, and supporters who help patients and families involved with T-cell therapy.  The foundation has a team of individuals who have come together to help inspire and create a brighter future for children, patients, and families.


The EWF offers an array of services that can benefit patients and families who need help with:

  • T-cell therapy information
  • Sharing experiences
  • Encouragement
  • Community support
  • Awareness
  • Patient advocacy
  • Resources
  • Cancer research


The Emily Whitehead Foundation is dedicated to raising awareness and funds for T-cell related therapy.  You can help by participating in a fundraising event or by donating.  For more information, you can visit the EWF’s website:

The Emily Whitehead Foundation 


See T-cells in action!

Fire With Fire Video with Dr. Carl June

Follow Nicole and other patients journeys:

Fighting Fire with Fire – Nicole’s Journey U Penn

Fighting For A Cure: A Friends Perspective



Kelly Marie Schwerin has been one of many friends who witnessed the chaos, struggle, and perseverance throughout my six year battle.  When I returned from Philadelphia from my CAR T Cell journey, it was Kellys birthday.  On October 26, 2016 this is what she wrote:

You touched down at the airport last night as the clock ticked my birthday. I can’t help but imagine how YOU are actually the Birthday Girl. I’ll GLADLY share October 5th with you. For on your fight for a cure, THIS is the day you return to your home in California. After multiple medical ‘death sentences’, you have been released from your struggle by diligent, unrelenting, Science. YOU made this happen. YOU fought for your place in this world. You never wavered. You never gave up hope. You DEMANDED your right to access CarT-Cell therapy, and you will now be the case study for the expansion of that study. You didn’t just save your own live. You created an entirely new group of standards for future participants. Yes, you fight for the cure on a large scale. But your individual fight for YOUR CURE has opened the door for countless others. YOU took one HUGE GAMBLE. You turned down a perfect bone marrow transplant match. You did it because you believed in what they were doing in Philadelphia. You took the ULTIMATE leap of faith. And in doing so, you have opened the door to save countless lives beyond your own. So I am BEYOND proud to share this day, my birthday, with you. In fact, I’m lucky in that YOU share it with me. I love you.