No Pain, No Gain

CAR T-cell Therapy Follow-up Visit – Month Three

This past Thursday was my three-month post CART22 checkup at Penn.  It was not the most exciting of my recent trips – especially since the appointment required a bone marrow (BM) biopsy procedure. Although I have had many of these over the years, I have never really gotten used to them. And this latest one was particularly rough.

What normally takes about 20 minutes ended up turning into a 40 minute procedure. A build up of scar tissue (from all of my previous biopsies) made it nearly impossible for the practitioner to access the deep part of the marrow. This made the procedure challenging for the practitioners and I think it made us all a little nervous.

Bone marrow biopsies are an important part of clinical research because they give insight to the deepest understanding of what is really going on in the blood cells. They are usually required before, during and after entering a clinical trial. A decent size specimen is needed because the marrow is eventually divided up and placed in tubes. These tubes go to various labs for research. One of the most crucial tests is for minimal residual disease (MRD). In my clinical trial, I am required to have these biopsies throughout the first year after completing the trial. One reason for this process is because research shows relapse from CAR T-cell therapy often happens within the first year.

I am sharing this experience because I want others to understand the undiscussed components that a cancer diagnosis gives a patient – both during and after treatment. It seems to never end; and for me, with each and every bone marrow biopsy, I am reminded of all the terrible things that I have had to get used to over the years.

On the flip side, each bone marrow biopsy also reminds me of how strong I have become, and how close I am to finally being near the end. It is also worth wile knowing that this type of research will ultimately benefit society.

As much as I would like to avoid the next biopsy or procedure, I have to remind myself that this is part of the clinical process. And it is a process that has given me a lot of love and light in life recently. Truthfully, enjoy watching science and spirituality intertwine as we progress in achieving our ultimate goal – a cure for cancer.

The test results from this latest biopsy will be a major milestone – not only for me, but also for the study.

I will be discussing the MRD results with my research team at Penn this Thursday, February 28th. Stay tuned for my next post where I will share these results 😃🙏🎗

The following photos have been provided help to illustrate what a bone marrow biopsy procedure might entail:

Bone Marrow Biopsy Procedure

 

Bone Marrow Biopsy Kit

 

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4 thoughts on “No Pain, No Gain

  1. Keep doing what you do girl! We are watching and praying for you and for ourselves that you are helping them find a cure.

    On another note big hugs because all these tests suck!

    Liked by 1 person

  2. Nicole,

    Thank you so much for sharing your experience with us and everyone who is also trying to navigate their way back to health. We are presently in search of a program for our son. I would love to speak with you to see if you can offer some guidance.

    Steve Reed 714-585-5069

    Liked by 1 person

    • Hi steve, thank you for reaching out. It will do my best to help you however I can. God bless your son and your family. Reaching out now…

      Like

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